General Cell Based Assays
ASSAYQUANT TECHNOLOGIES INC Protein 1000 kin assay AQT0911
PhosphoSens-Kinetic Kinase Activity Kit 1000 assays - AQT0911
Cayman Chemical UrIc AcId Enzyme MIxture 1ea
An H /K -ATPase inhibitor reversibly inhibits the activity of the H /K -ATPase in an enzyme assay inhibits histamine-induced gastric acid secretion in rats at 30 mg/kg s.c.
Eurofins Discoverx PathHunter eXpress ErbB2-ErbB3 Functional Assay, 10pl Kit. (93-0535E3CP16L)
The PathHunter eXpress ErbB2-ErbB3 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated ErbB2 and ErbB3 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged ErbB2 and an EA-tagged SH2 domain protein. It also overexpresses an untagged coreceptor, ErbB3 Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CXCR2 Activated GPCR Internalization Assay, 10pl Kit. (93-0934E3CP5L)
The PathHunter CXCR2 Activated GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of CXCR2 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged CXCR2. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting CXCR2-arrestin complex is internalized to the early endosome, leading to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx cAMP Hunter eXpress CRHR1 CHO-K1 GPCR Assay, 10-Plate Kit. (95-0047E2CP2L)
The cAMP Hunter CRHR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CRH, sauvagine) based activation of CRHR1 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CRHR1, a naturally Gs coupled GPCR. Upon activation of CRHR1, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress GPR182 CHO-K1 β-Arrestin Orphan GPCR Assay, 2-Plate Kit. (93-0754E2CP1M)
The PathHunter GPR182 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR182 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR182 and EA-tagged β-Arrestin-2. Activation of GPR182 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
ASSAYQUANT TECHNOLOGIES INC Protein 1000 kin assay AQT0972
PhosphoSens-Kinetic Kinase Activity Kit 1000 assays - AQT0972
Eurofins Discoverx PathHunter Human TGFBR1/ACVR2 Dimerization Cell-Based Assay Kit (U2OS)
The PathHunter Human TGFBR1/ACVR2 Dimerization Stable Cell Line Assay (U2OS) measures ligand-induced dimerization of TGFBR1A/ACVR2A. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human PDGFRb Functional Kinase Cell-Based Assay Kit (U2OS)
The PathHunter Human PDGFRb Stable Cell Line Functional Kinase Assay (U2OS) measures PDGFRb receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human MRGPRX2 β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human MRGPRX2 β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure MRGPRX2 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx InCELL Hunter eXpress CLK2 Kinase Binding Assay, 10pl Kit. (96-0057E15CP0L)
The InCELL Hunter eXpress CLK2 Kinase Binding Assay provides an easy-to-use cell based assay to study small molecule drug candidates that engage with kinases. This kit assesses compound-engagement-based stabilization of CLK2 via detection of CLK2 levels. This product uses EFC technology. The cell line included overexpresses CLK2 target protein fused to ProLabel. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CXCR3 Activated GPCR Internalization Assay, 10pl Kit. (93-0661E3CP0L)
The PathHunter CXCR3 Activated GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of CXCR3 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged CXCR3. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting CXCR3-arrestin complex is internalized to the early endosome, leading to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx cAMP Hunter eXpress GPR109B CHO-K1 GPCR Assay, 10-Plate Kit. (95-0141E2CP2L)
The cAMP Hunter GPR109B eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. 3-hydroxyoctanoic acid) based activation of GPR109B GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type GPR109B, a naturally Gi/Go coupled GPCR. Upon activation of GPR109B, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter Human Complement C5a (C5AR1) Activated GPCR Internalization Cell-Based Assay Kit (U2OS)
The PathHunter Human Complement C5a (C5AR1) Stable Cell Line Activated Internalization Assay (U2OS) contains a stable clonal cell line used to measure C5AR1 (GPCR) internalization via early-endosome localization. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human EphA5 Functional Kinase Cell-Based Assay Kit (U2OS)
The PathHunter Human EphA5 Stable Cell Line Functional Kinase Assay (U2OS) measures EphA5 receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.